A very common question from runners and athletes is can I get a cortisone shot to help with my ankle sprain? The answer is yes. You can get one and in the short term it will decrease your pain. However, in the long term it will only make your ankle worse. The steroid will preciptate in the area as well as retard healing of the ankle sprain. The only times a cortisone shot for an ankle sprain should be considered is if you HAVE to play in a certain game, like the last game of your high school career. Otherwise cortisone shots are not worth the trade off due to their deleterious effects.